The Snyder lab received its first National Institutes of Health R01 award studying the role of tissue resident memory T cells in chronic lung allograft dysfunction.
PROJECT NARRATIVE
Chronic lung allograft dysfunction (CLAD) is a progressive fibrosis of the airway and/or lung parenchyma that is the primary limiting factor for long-term survival after lung transplantation. During acute cellular rejection, recipient-derived T cells infiltrate the lung allograft, migrate to the airways where CLAD predominantly occurs, and persist within the transplanted lungs as long-lived tissue resident memory T cells (TRM). This research project investigates the role of alloreactive recipient derived TRM in the development of CLAD after lung transplantation and explores the impact of commonly used immune modulators on TRM persistence, phenotype, and function.
Source: NIH RePORTER